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RSV Vaccine Made Possible With Adjuvant Technology

The FDA approved Arexvy, GSK's RSV vaccine, to prevent hospitalizations in adults 60+ years old. The vaccine incorporates GSK's AS01 adjuvant formulation. Learn more about the importance of adjuvants and how they play a role in protecting vulnerable populations against various diseases. 


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MAY 2023

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Seattle, WA

World Malaria Day 2023 - Time to deliver zero malaria: invest, innovate, implement

AAHI provides adjuvant formulations to partners around the world to enable cost-effective malaria vaccine candidates that can be made equitably accessible to people in areas most burdened by malaria-carrying mosquitoes, such as Africa, India, and Brazil. Although malaria is curable, malaria parasites claimed over 600,000 lives and infected 200 million people in 2021 alone. While travelers like Seattle Sounders' Nouhou Tolo can return home to access treatment, the treatment is not ready accessible to residents of, for example, Uganda, Mozambique, and Tanzania. The sole approved malaria vaccine, Mosquirix, is approved in Ghana and Nigeria for young children, but there continues to be an urgen unmet global need for malaria vaccines for older children, adults, and pregnant women. 

Learn more about malaria vaccine candidates targeting varous strains of the disease that are in clinical development. 

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By Anthony King

Chemistry World

One of the most successful vaccine adjuvants – QS-21 – is derived from saponin compounds in the bark of the rare Chilean soapbark tree Quillaja Saponaria.  QS-21 is a component of GSK’s Shingrix®, Mosquirix®, and Arexyv® vaccines, Novavax’s Nuvaxovid® vaccine, and several leading malaria and tuberculosis vaccine candidates. Researchers are exploring more sustainable ways to source saponin to keep up with growing demand.

Scientists at John Innes Centre in Norwhich, UK, identified the specific pathway by which Chilean soapbark trees synthesize saponins.  This isa significant step toward understanding how these rare trees can be induced to produce saponin in parts of the tree other than its bark, for more sustainable and higher volume production.


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Openings and Opportunities


The Scientist I/II (Product Development) will be responsible for establishing, managing, and executing process development, formulation development, and delivery device development and testing and associated analytical capabilities. 


The Scientist I/II/Senior Scientist will be responsible for broadening the applications of AAHI's RNA vaccine platform to a wide range of infectious disease and oncology targets and will lead a growing, multi-level, early development team to bring novel RNA vaccine candidates to the initiation of Phase 1 clinical trials. 

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Synthetic TLR4 ligand in squalene nanoemulsion

Synthetic TLR4 ligand in QS- 21 containing liposome

Synthetic TLR4 ligand in aqueous formulation

Dual agonist containing both TLR4 and TLR7/8 ligands

2nd-Gen synthetic TLR4 ligand
in squalene nanoemulsion

2nd-Gen synthetic TLR4 ligand
in QS-21 containing liposome

2nd-Gen synthetic TLR4 ligand
in aqueous formulation

Alum nanoparticle formulation, customized particle size

Synthetic TLR7/8 ligand in
squalene nanoemulsion

Synthetic TLR7/8 ligand
adsorbed to aluminum

Synthetic TLR7/8 ligand in
aqueous formulation

Nanostructured lipid carrier

See how our formulations are being used.

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