AAHI NEWS

Innovations • Global Impact • In The News • Our People

Adjuvant formulations - a tipping point for global health? 

Major milestones for advancing vaccines against tuberculosis and malaria were announced last month, all relying on adjuvant formulation technology. AAHI scientists share their practical and creative approach to adjuvant development to establish sustainable and resilient global health infrastructure.

INNOVATIONS

The latest scientific breakthroughs at AAHI.

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GLOBAL IMPACT

JULY 2023

Collaboration across communities.

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Burkina Faso, Madagascar

Tropical disease transmitted by worms on verge of being curbed

Schistosomiasis is a complex target because the parasitic flatworm that causes the disease is long-lived and versatile, with an ever-mutating surface membrane that complicates immune responses. No vaccine exists to provide protection against this neglected tropical disease that has infected over 140 million people. A new schistosomiasis vaccine candidate that recently completed first-in-human clinical trials in Seattle, WA provides growing hope for protection. The candidate uses AAHI's GLA-SE adjuvant formulation. The vaccine candidate will be evaluated in clinical trails in Madagascar and Burkina Faso, where Schistosomiasis is endemic.

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NEWS WE FOLLOW

By Amy Maxmen

The Washington Post

Amy Maxmen discusses the challenges in sustaining efforts such as mRNA vaccine technology transfer hub initiative launched by the World Health Organization to share mRNA technology development and manufacturing worldwide. 

AAHI is committed to simplifying RNA vaccine development by creating temperature stable vaccine technologies with sustainable, streamlined manufacturing processes to establish efficient healthcare infrastructure worldwide. 

"The pandemic showed us that you can't depend on others when the world is competing for a resource. We need to make our own." - Sotriis Missailidis, director of innovation at the government research institute Bio-Manguinhos/Fiocruz, whom AAHI partnered with to develop vaccines against hookworm and schistosomiasis. 

OUR PEOPLE

Collaboration across communities.

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Featured Post

At this year's Military Health System Research Symposium, the DoD premier scientific meeting to discuss medical countermeasures, Emily Voigt, PhD, Principal Scientist and leader of AAHI's RNA vaccine platform, will present the promising results of AAHI's research on: 

1) The intranasal administration of AAHI's RNA vaccine technologies to provide enhanced protection against viral respiratory infection and transmission of disease

2) preclinical evaluation of AAHI's yellow fever RNA vaccine candidate slated to enter clinical trials in 2024 with the support of the NIH

Openings and Opportunities

Research

The Scientist I/II/Senior Scientist will be responsible for broadening the applications of AAHI's RNA vaccine platform to a wide range of infectious disease and oncology targets and will lead a growing, multi-level, early development team to bring novel RNA vaccine candidates to the initiation of Phase 1 clinical trials. 

Research

The Associate/Staff Scientist will be responsible for directing the in vivo mouse immunology studies on the RNA team, providing support to conduct in vivo aspects of product stability and release testing studies for AAHI's Product Development and GMP teams as necessary.

Learn more about our formulation technology

We partner with biotech leaders to develop vaccines and more.

Synthetic TLR4 ligand in squalene nanoemulsion

Synthetic TLR4 ligand in QS- 21 containing liposome

Synthetic TLR4 ligand in aqueous formulation

Dual agonist containing both TLR4 and TLR7/8 ligands

2nd-Gen synthetic TLR4 ligand
in squalene nanoemulsion

2nd-Gen synthetic TLR4 ligand
in QS-21 containing liposome

2nd-Gen synthetic TLR4 ligand
in aqueous formulation

Alum nanoparticle formulation, customized particle size

Synthetic TLR7/8 ligand in
squalene nanoemulsion

Synthetic TLR7/8 ligand
adsorbed to aluminum

Synthetic TLR7/8 ligand in
aqueous formulation

Nanostructured lipid carrier

See how our formulations are being used.