Innovations • Global Impact • In The News • Our People
AAHI Hosts the Next Generation of Scientists
AAHI was delighted to host Shoreline Community College biotechnology students for a tour of AAHI facilities to learn more about what goes into developing a vaccine product from the laboratory bench to manufacturing for human clinical trials.
The latest scientific breakthroughs at AAHI.
AAHI Develops Sustainable Alternatives to Critical Vaccine Components Currently Sourced from Shark Liver
Christopher Fox, Senior VP, Formulations, collaborated with Amyris to create 20+ different compounds that are potential alternatives to natural squalene, an immune-stimulating substance (adjuvant) that is derived from shark liver oil and used in seasonal influenza vaccines, including FLUAD, and several licensed COVID-19 vaccines. Researchers included the alternative compounds in experimental flu vaccines and tested them in preclinical models, confirming that compounds stimulate immune responses. The study marks considerable progress toward a functional squalene alternative that could alleviate the population pressure on endangered shark species.
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AAHI Partners with the Department of Defense to Develop a Nasal Spray that Could be Broadly Protective Against a Wide Spectrum of Respiratory Viruses
AAHI is awarded $3 million to develop an intranasal pan-viral countermeasure against respiratory viruses. AAHI scientists will develop a prototype nasal spray using AAHI's novel formulation of two immune-stimulating adjuvants (TLR agonists) as a pre-exposure prophylactic against infectious respiratory diseases, including novel viruses and newly emerging variants of existing viruses. AAHI scientists will test the nasal spray against pandemic influenza and Nipah virus in preclinical studies. If successful, the activities under the award will support rapid initiation of Phase 1 clinical trials in humans.
AAHI Attends the World Vaccine Congress 2023
We look forward to participating in the most important vaccine event of the year. Our team would love to meet with you - stop by our booth #805 to learn more about AAHI's immune-enhancing platform technologies and how they enable equitable access to health solutions around the world.
Help us make impossible vaccines possible.
IN THE NEWS
By Anthony King
Shark-derived squalene has been used in hundreds of millions of doses of vaccine, including for flu and Covid-19 and is in candidate vaccines for tuberculosis and malaria. "Our vision is to develop next generation vaccines, whether for influenza or Covid, using such compounds," Christopher Fox tells Chemistry World, "Additional preclinical work in different animal models is needed to establish protective efficacy and safety."
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Openings and Opportunities
The Quality Assurance Associate I/II will be responsible for workforce assessments, providing training to new employees, producing and approving documentation and progress reports, and collaborating with colleagues to ensure everything is running smoothly and complies with company policies and regulations.
The Quality Control Associate I/II will be responsible for performing anlaytical tests, gathering and assessing data from those tests, and writing documentation and reports. The candidate will work in quality control laboratories in a GMP Manufacturing setting.
The Associate / Staff Scientist will be responsible for managing and executing formulation development
and stability studies, including collecting, analyzing, reviewing, and reporting bulk antigen and drug
product characterization for multiple projects.
The Associate / Staff Scientist will be responsible for performing assay development, optimizations and
validations, preparation of blood specimens for ex vivo assays under BSL 2 conditions, performing a
variety of immunological assays, and assisting in drafting manuscripts.
The Senior Scientist joining our RNA vaccine team will be responsible for broadening the applications of
AAHI's RNA vaccine platform to a wide range of infectious disease and oncology targets.
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We partner with biotech leaders to develop vaccines and more.
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