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AAHI pioneers immune-enhancing platforms to provide potent, durable, broadly effective, and efficient vaccine and immunotherapy solutions that are accessible to those who need them most.
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More Durable, Broader Spectrum Boosters Needed Against COVID-19
From the fringes to the forefront - the mRNA era has taken hold of pharma
Pan-coronavirus vaccine pipeline takes form
The Access To Advanced Health Institute Receives $26 Million Donation from the Chan Soon-Shiong Family Foundation to Further Develop Immune-Enhancing Platform Technology
Released from court oversight, a Seattle research institution rebrands and resets
Infectious Disease Research Institute Exits Receivership and Launches AAHI, the Access to Advanced Health Institute, with $50 Million Funding Commitment
Featured Publication
A flexible, thermostable nanostructured lipid carrier platform for RNA vaccine delivery
Current RNA vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are limited by instability of both the RNA and the lipid nanoparticle delivery system, requiring storage at −20°C or −70°C and compromising universally accessible vaccine distribution. This study demonstrates the thermostability and adaptability of a nanostructured lipid carrier (NLC) delivery system for RNA vaccines that has the potential to address these concerns. Liquid NLC alone is stable at refrigerated temperatures for ≥1 year, enabling stockpiling and rapid deployment by point-of-care mixing with any vaccine RNA. Alternatively, NLC complexed with RNA may be readily lyophilized and stored at room temperature for ≥8 months or refrigerated temperature for ≥21 months while still retaining the ability to express protein in vivo. The thermostability of this NLC/RNA vaccine delivery platform could significantly improve distribution of current and future pandemic response vaccines, particularly in low-resource settings.
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